Acetic acid is widely used for ion suppression in HPLC. Please note the UV absorption of Acetic acid, and don't use it at low wavelength. If you need to work at low wavelength, use phosphoric acid instead, and be careful to check the pH does not go below 2.0. (If a bonded phase is attached by a siloxane bond to a column, this is hydrolysed below pH2)
Note that acetic acid is only a liquid over 17C! And be careful not to spill it on skin. Mineral acids may take a second or so to burn through the grease on skin, but acetic acid cuts through really fast and gives a very nasty burn. Also be careful if smelling a bottle of glacial acetic acid. The vapour is enough to burn in the lungs, and the intense smell makes it all but impossible to breathe.
For further details about acetic acid see the Wikipedia page:
Acetic Acid |